Molecular mechanisms of endothelial differentiation

The differentiation of embryonic stem cells along the endothelial cell lineage requires a tightly coordinated sequence of events that are regulated in both space and time. Although significant gaps remain in this process, major strides have been made over the past 10 years in identifying the growth...

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Bibliographic Details
Published in:Vascular medicine (London, England) England), 2010-08, Vol.15 (4), p.321-331
Main Authors: Le Bras, Alex, Vijayaraj, Preethi, Oettgen, Peter
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood and lymphatic vessels
Blood. Blood coagulation. Reticuloendothelial system
Cardiology. Vascular system
Cell Differentiation - physiology
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Embryonic Stem Cells - cytology
Embryonic Stem Cells - metabolism
Endothelial Cells - cytology
Endothelial Cells - metabolism
Hematopoietic Stem Cells - cytology
Hematopoietic Stem Cells - metabolism
Humans
Medical sciences
Pharmacology. Drug treatments
Signal Transduction - physiology
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Summary:The differentiation of embryonic stem cells along the endothelial cell lineage requires a tightly coordinated sequence of events that are regulated in both space and time. Although significant gaps remain in this process, major strides have been made over the past 10 years in identifying the growth factors, signal transduction pathways, and transcription factors that function together as critical mediators of this process. Examples of some of the signal transduction pathways include the hedgehog (HH), WNT, BMP, and Notch pathways. A complex interplay between growth factors, and activation of a variety of signal transduction pathways leads to the induction of transcriptional programs that promote the differentiation of embryonic stem cells along the endothelial lineage and ultimately into arterial, venous, and lymphatic endothelial cells. The purpose of this review is to summarize the recent advances in our understanding of the molecular mechanisms underlying endothelial differentiation.
ISSN:1358-863X
1477-0377
DOI:10.1177/1358863X10371685