Pre-eclampsia

Summary Pre-eclampsia remains a leading cause of maternal and perinatal mortality and morbidity. It is a pregnancy-specific disease characterised by de-novo development of concurrent hypertension and proteinuria, sometimes progressing into a multiorgan cluster of varying clinical features. Poor earl...

Full description

Saved in:
Bibliographic Details
Published in:The Lancet (British edition) 2010-08, Vol.376 (9741), p.631-644
Main Authors: Steegers, Eric AP, Prof, von Dadelszen, Peter, MBChB, Duvekot, Johannes J, MD, Pijnenborg, Robert, Prof
Format: Article
Language:English
Subjects:
Biological and medical sciences
Diagnosis, Differential
Diseases of mother, fetus and pregnancy
Female
General aspects
Gynecology. Andrology. Obstetrics
Humans
Hypertension
Internal Medicine
Medical research
Medical sciences
Metabolic disorders
Morbidity
Mortality
Pre-Eclampsia - diagnosis
Pre-Eclampsia - physiopathology
Pre-Eclampsia - therapy
Pregnancy
Pregnancy. Fetus. Placenta
Veins & arteries
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Pre-eclampsia remains a leading cause of maternal and perinatal mortality and morbidity. It is a pregnancy-specific disease characterised by de-novo development of concurrent hypertension and proteinuria, sometimes progressing into a multiorgan cluster of varying clinical features. Poor early placentation is especially associated with early onset disease. Predisposing cardiovascular or metabolic risks for endothelial dysfunction, as part of an exaggerated systemic inflammatory response, might dominate in the origins of late onset pre-eclampsia. Because the multifactorial pathogenesis of different pre-eclampsia phenotypes has not been fully elucidated, prevention and prediction are still not possible, and symptomatic clinical management should be mainly directed to prevent maternal morbidity (eg, eclampsia) and mortality. Expectant management of women with early onset disease to improve perinatal outcome should not preclude timely delivery—the only definitive cure. Pre-eclampsia foretells raised rates of cardiovascular and metabolic disease in later life, which could be reason for subsequent lifestyle education and intervention.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(10)60279-6