Loading…

Unnatural enantiomer of chaetocin shows strong apoptosis-inducing activity through caspase-8/caspase-3 activation

The unnatural enantiomer of chaetocin ( ent-chaetocin) was more potent than chaetocin, and was found to induce apoptosis through the caspase-8/caspase-3 activation pathway. Chaetocin, a natural product isolated from Chaetomium species fungi, was reported to have various biological activities, includ...

Full description

Saved in:
Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2010-09, Vol.20 (17), p.5085-5088
Main Authors: Teng, Yuou, Iuchi, Katsuya, Iwasa, Eriko, Fujishiro, Shinya, Hamashima, Yoshitaka, Dodo, Kosuke, Sodeoka, Mikiko
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The unnatural enantiomer of chaetocin ( ent-chaetocin) was more potent than chaetocin, and was found to induce apoptosis through the caspase-8/caspase-3 activation pathway. Chaetocin, a natural product isolated from Chaetomium species fungi, was reported to have various biological activities, including antitumor and antifungal activities. Recently, we reported the first total synthesis of chaetocin and its derivatives. Here, we examined the cell-death-inducing activity of these compounds in human leukemia HL-60 cells. The unnatural enantiomer of chaetocin ( ent-chaetocin) was more potent than chaetocin, and was found to induce apoptosis through the caspase-8/caspase-3 activation pathway.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2010.07.032