A selective, cell-permeable fluorescent probe for Al3+ in living cells

The synthesis and evaluation of a novel Schiff-base fluorescent probe L for detection of Al(3+) are described. The structure of L was determined by X-ray and other spectroscopic data. The fluorescent spectra changes and microscopy images show that indicator L is highly selective for Al(3+) not only...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2010-08, Vol.8 (16), p.3751-3757
Main Authors: Wang, Lina, Qin, Wenwu, Tang, Xiaoliang, Dou, Wei, Liu, Weisheng, Teng, Qingfeng, Yao, Xiaojun
Format: Article
Language:English
Subjects:
Aluminum - analysis
Aluminum - chemistry
Cations - chemistry
Cell Membrane Permeability
Cell Survival
Fluorescent Dyes - chemical synthesis
Fluorescent Dyes - metabolism
Humans
Hydrogen-Ion Concentration
K562 Cells
Models, Molecular
Molecular Conformation
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Summary:The synthesis and evaluation of a novel Schiff-base fluorescent probe L for detection of Al(3+) are described. The structure of L was determined by X-ray and other spectroscopic data. The fluorescent spectra changes and microscopy images show that indicator L is highly selective for Al(3+) not only in abiotic systems but also in living cells. Other metal ions failed to respond. The new probe could be used as an efficient tool for Al(3+) monitoring in the environment and biological systems.
ISSN:1477-0520
1477-0539
DOI:10.1039/c0ob00123f