BINDING SITE OF OUABAIN IN CARDIAC MUSCLE CELL AND ITS POSITIVE INOTROPIC EFFECT IN CAT

A study was conducted to know the significance of ouabain-binding to various structural components of cardiac muscle cell in appearance of the positive inotropic effect. A special attention was paid to the binding capacity in two kinds of membrane system, sarcoplasmic reticulum (SR) and cell membran...

Full description

Saved in:
Bibliographic Details
Published in:Japanese journal of pharmacology 1971, Vol.21 (3), p.423-425
Main Authors: FUJINO, Sumiko, KAWAGISHI, Shunsaku, EGUCHI, Noriyasu, TANAKA, Mamoru
Format: Article
Language:English
Subjects:
Adenosine Triphosphatases - antagonists & inhibitors
Animals
Binding Sites
Calcium - metabolism
Calcium Isotopes
Cats
Cell Membrane - analysis
Cell Nucleus - analysis
Endoplasmic Reticulum - analysis
Microsomes - analysis
Mitochondria, Muscle - analysis
Muscle Contraction - drug effects
Muscles - analysis
Myocardium - analysis
Myocardium - metabolism
Ouabain - analysis
Ouabain - metabolism
Ouabain - pharmacology
Tritium
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A study was conducted to know the significance of ouabain-binding to various structural components of cardiac muscle cell in appearance of the positive inotropic effect. A special attention was paid to the binding capacity in two kinds of membrane system, sarcoplasmic reticulum (SR) and cell membrane, since it has been pointed out that Ca-mobilizing effect of cardiac glycosides on SR and/or cell membrane is responsible for the positive inotropic effect (1–3), suggesting a selective affinity of the glycosides to a cellular component.
ISSN:0021-5198
1347-3506
DOI:10.1016/S0021-5198(19)36238-9