Clinical and radiological features of Takayasu’s arteritis patients in Jordan

The prevalence of Takayasu’s arteritis (TA) varies greatly among world populations, and little is known about this disease in Eastern Mediterranean Arab populations. We conducted a retrospective chart review of patients diagnosed with TA from 1996 to 2008 at a single large referral center in Jordan....

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Bibliographic Details
Published in:Rheumatology international 2010-09, Vol.30 (11), p.1449-1453
Main Authors: Mustafa, Khader N., Hadidy, Azmy, Sweiss, Nadera J.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Arabs - genetics
Comorbidity - trends
Female
Follow-Up Studies
Humans
Jordan - epidemiology
Jordan - ethnology
Magnetic Resonance Angiography
Male
Medicine
Medicine & Public Health
Middle Aged
Original Article
Prevalence
Radiography
Retrospective Studies
Rheumatology
Takayasu Arteritis - diagnosis
Takayasu Arteritis - diagnostic imaging
Takayasu Arteritis - mortality
Young Adult
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Summary:The prevalence of Takayasu’s arteritis (TA) varies greatly among world populations, and little is known about this disease in Eastern Mediterranean Arab populations. We conducted a retrospective chart review of patients diagnosed with TA from 1996 to 2008 at a single large referral center in Jordan. Eight patients (seven females, one male) with angiographically diagnosed TA were seen at the Jordan University Hospital between 1996 and 2008. All patients were of Arabic ethnicity. The age at presentation ranged from 14 to 50 years, and delay in diagnosis ranged from 1 to 10 years. Extra-vascular manifestations included nodular episcleritis, elevated liver enzymes, erythema nodosum, inflammatory-bowel-disease-like illness, Raynaud’s phenomena, and constitutional symptoms. Vascular symptoms included postural dizziness, central nervous system deficits, amauroses fugax, and transient ischemic attacks. Aortic arch vessels were involved in all patients, the abdominal aorta was involved in five patients, and the renal arteries in four patients. Major clinical events including severe stroke and cardiac failure were associated with mortality in two patients. Treatment with corticosteroids and immunosuppressive agents resulted in improvement in five patients with follow-up ranging from 3 to 12 years. In conclusion, TA is seen in Arabs, and the clinical spectrum of TA in Arabs in Jordan is similar to that reported in other countries. Increased awareness of the disease may shorten the time to diagnosis and result in a more reliable estimate of disease prevalence.
ISSN:0172-8172
1437-160X
DOI:10.1007/s00296-009-1163-5