PTSD and dopaminergic genes, DRD2 and DAT, in multigenerational families exposed to the Spitak earthquake

Abstract The objective of this study was to assess the generality of the association of DRD2 and DAT genes and Post-Traumatic Stress Disorder (PTSD) diagnosis/symptom severity. Two hundred ethnic Armenians from 12 multigenerational families exposed to the catastrophic 1988 Spitak earthquake were stu...

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Bibliographic Details
Published in:Psychiatry research 2010-08, Vol.178 (3), p.507-510
Main Authors: Bailey, Julia N, Goenjian, Armen K, Noble, Ernest P, Walling, David P, Ritchie, Terry, Goenjian, Haig A
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Anxiety disorders. Neuroses
B category symptoms
Biological and medical sciences
DAT
Dopamine Plasma Membrane Transport Proteins - genetics
DRD2
Earthquakes
Family Health
Female
Gene Frequency
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Heritability
Humans
Male
Medical sciences
Polymorphism, Genetic - genetics
Post-traumatic stress disorder
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychometrics - methods
Psychopathology. Psychiatry
PTSD
Receptors, Dopamine D2 - genetics
Stress Disorders, Post-Traumatic - diagnosis
Stress Disorders, Post-Traumatic - genetics
Stress Disorders, Post-Traumatic - psychology
Trinucleotide Repeat Expansion - genetics
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Summary:Abstract The objective of this study was to assess the generality of the association of DRD2 and DAT genes and Post-Traumatic Stress Disorder (PTSD) diagnosis/symptom severity. Two hundred ethnic Armenians from 12 multigenerational families exposed to the catastrophic 1988 Spitak earthquake were studied. Common polymorphisms A1/A2 alleles of the DRD2 and ‘9’ repeat allele of DAT gene were genotyped. Heritability, association and linkage were assessed using variance component genetic analyses. After adjusting for the covariates, the heritabilities of PTSD diagnosis and B and C category symptoms were: 0.37, 0.75 and 0.39 respectively. Category D symptoms were not heritable. Neither the DRD2 nor the DAT polymorphisms explained the variation seen in PTSD diagnosis, total PTSD symptom severity, and categories B and C symptom severities. These findings contradict prior reports of positive associations between both DRD2 and DAT, and PTSD.
ISSN:0165-1781
1872-7123
DOI:10.1016/j.psychres.2010.04.043