Efforts toward elucidating Thalidomide's molecular target: an expedient synthesis of the first Thalidomide biotin analogue

Herein we describe the synthesis of the first Thalidomide-biotin analogue in order to initiate investigations into the unknown molecular mode of action of Thalidomide. In this manner we describe the attachment of biotin tether through the Huisgen 1,3-dipolar cycloaddition or "click" synthe...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2010-09, Vol.8 (18), p.4059-4062
Main Authors: Stewart, Scott G, Braun, Carlos J, Polomska, Marta E, Karimi, Mahdad, Abraham, Lawrence J, Stubbs, Keith A
Format: Article
Language:English
Subjects:
Biotin - chemical synthesis
Biotin - chemistry
Molecular Structure
Polyethylene Glycols - chemistry
Stereoisomerism
Thalidomide - chemical synthesis
Thalidomide - chemistry
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Summary:Herein we describe the synthesis of the first Thalidomide-biotin analogue in order to initiate investigations into the unknown molecular mode of action of Thalidomide. In this manner we describe the attachment of biotin tether through the Huisgen 1,3-dipolar cycloaddition or "click" synthetic methodology.
ISSN:1477-0520
1477-0539
DOI:10.1039/c0ob00060d