Ten years later: A single hospital experience with malignancy in HIV/AIDS

Background and Objective We present our experience in the era of HAART with 5,112 patients having HIV infection or AIDS, treated between 2002 and 2006 in our hospital, 182 of whom had malignancies (3.56%). We compared our findings to those from a similar cohort of patients studied 10 years earlier....

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Published in:Journal of surgical oncology 2010-09, Vol.102 (3), p.282-286
Main Authors: Reed, Mary, Cosgrove, John M., Cindrich, Richard, Parithivel, Vellore S., GAD, Youhanna, Bangalore, Madan, Uzor, Robert, Kalim, Jawaid, Segura, Raymundo, Albu, Eugene
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome - complications
Acquired Immunodeficiency Syndrome - drug therapy
Adult
Aged
Aged, 80 and over
AIDS
Antiretroviral Therapy, Highly Active
Female
Follow-Up Studies
HIV
HIV Infections - complications
HIV Infections - drug therapy
Humans
Incidence
Male
malignancy
Middle Aged
Neoplasms - epidemiology
Neoplasms - mortality
Sarcoma, Kaposi - epidemiology
stages
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Summary:Background and Objective We present our experience in the era of HAART with 5,112 patients having HIV infection or AIDS, treated between 2002 and 2006 in our hospital, 182 of whom had malignancies (3.56%). We compared our findings to those from a similar cohort of patients studied 10 years earlier. Methods The charts were reviewed and data was electronically collected as in our 1993–1998 study. Similar statistical analyses were performed in both studies and the results were compared. Results For the current study the average patient age increased by 9 years. A decrease in AIDS‐defining cancers (ADC), from 63.6% to 37.3% and a higher incidence of non‐AIDS‐defining cancers (NADC), 62.7 as opposed to 37.9% was found. No decrease in the incidence of non‐Hodgkin's B cell lymphoma (NHL) was noted. There was an increase in the number of opportunistic infections notably hepatitis C virus (HCV) and hepatitis B virus (HBV). Conclusions HIV/AIDS patients on HAART are older, have lower rates of AIDS related Kaposi's sarcoma and a higher incidence of NADCs than did patients in the early HAART era. No decrease in the proportion of NHL was observed. J. Surg. Oncol. 2010;102:282–286. © 2010 Wiley‐Liss, Inc.
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.21590