Simple and Efficient Preparation of 2,5-Disubstituted Oxazoles via a Metal-Free-Catalyzed Cascade Cyclization

A practical and simple synthesis of 2,5-disubstituted oxazoles was developed via an iodine-catalyzed tandem oxidative cyclization. A wide range of common commercial aromatic aldehydes can be used as reaction substrates, which displayed excellent functional group compatibility in this reaction.

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Bibliographic Details
Published in:Organic letters 2010-09, Vol.12 (17), p.3902-3905
Main Authors: Wan, Changfeng, Gao, Linfeng, Wang, Qiang, Zhang, Jintang, Wang, Zhiyong
Format: Article
Language:English
Subjects:
Aldehydes - chemistry
Catalysis
Cyclization
Iodine - chemistry
Molecular Structure
Oxazoles - chemical synthesis
Oxazoles - chemistry
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Description
Summary:A practical and simple synthesis of 2,5-disubstituted oxazoles was developed via an iodine-catalyzed tandem oxidative cyclization. A wide range of common commercial aromatic aldehydes can be used as reaction substrates, which displayed excellent functional group compatibility in this reaction.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol101596s