Cell–Matrix Adhesion: Slip and Immobilization under Force

When force is applied to cell–matrix adhesion complexes, they respond by growing larger and stronger. It emerges that strengthening involves transient motion of the transmembrane integrin receptors and their eventual immobilization to the extracellular matrix.

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Bibliographic Details
Published in:Current biology 2010-08, Vol.20 (16), p.R669-R671
Main Author: Verkhovsky, Alexander B.
Format: Article
Language:English
Subjects:
Cell Adhesion - physiology
Cell Line
Extracellular Matrix - physiology
Focal Adhesions
Humans
Integrins - physiology
Myosin Type II - physiology
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Description
Summary:When force is applied to cell–matrix adhesion complexes, they respond by growing larger and stronger. It emerges that strengthening involves transient motion of the transmembrane integrin receptors and their eventual immobilization to the extracellular matrix.
ISSN:0960-9822
1879-0445
DOI:10.1016/j.cub.2010.06.030