Bleb Morphology and Vascularity After Trabeculectomy With Intravitreal Ranibizumab: A Pilot Study

Purpose To investigate outcomes after trabeculectomy using intraoperative intravitreal ranibizumab and topical mitomycin C (MMC) vs MMC alone. Design Prospective randomized single-site pilot study. Methods Patients diagnosed with primary open-angle glaucoma were randomized 1:1 to either combination...

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Bibliographic Details
Published in:American journal of ophthalmology 2010-09, Vol.150 (3), p.399-403.e1
Main Author: Kahook, Malik Y
Format: Article
Language:English
Subjects:
Aged
Alkylating Agents - administration & dosage
Angiogenesis Inhibitors - administration & dosage
Antibodies, Monoclonal - administration & dosage
Antibodies, Monoclonal, Humanized
Biological and medical sciences
Blister - pathology
Cell Count
Combined Modality Therapy
Conjunctiva - blood supply
Endothelium, Corneal - pathology
Glaucoma, Open-Angle - drug therapy
Glaucoma, Open-Angle - surgery
Humans
Injections
Intraocular Pressure
Medical sciences
Middle Aged
Miscellaneous
Mitomycin - administration & dosage
Neovascularization, Pathologic - pathology
Ophthalmology
Pilot Projects
Prospective Studies
Ranibizumab
Trabeculectomy
Treatment Outcome
Vitreous Body
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Summary:Purpose To investigate outcomes after trabeculectomy using intraoperative intravitreal ranibizumab and topical mitomycin C (MMC) vs MMC alone. Design Prospective randomized single-site pilot study. Methods Patients diagnosed with primary open-angle glaucoma were randomized 1:1 to either combination intravitreal ranibizumab 0.5 mg and topically applied MMC (0.4 mg/mL for 2 min) or MMC (0.4 mg/mL for 2 min) therapy alone at time of trabeculectomy surgery. The primary endpoint measured was bleb morphology and vascularity using the Moorfields Bleb Grading System. Unqualified success was defined as postoperative intraocular pressure (IOP) of >5 and 5 and
ISSN:0002-9394
1879-1891
DOI:10.1016/j.ajo.2010.03.025