Transmembrane 4 L six family member 5 (TM4SF5) enhances migration and invasion of hepatocytes for effective metastasis

Overexpression of transmembrane 4 L six family member 5 (TM4SF5), a four‐transmembrane L6 family member, causes aberrant cell proliferation and angiogenesis, but the roles of TM4SF5 in migration, invasion, and tumor metastasis remain unknown. Using in vitro hepatocarcinoma cells that ectopically or...

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Published in:Journal of cellular biochemistry 2010-09, Vol.111 (1), p.59-66
Main Authors: Lee, Sin-Ae, Kim, Tae You, Kwak, Tae Kyoung, Kim, Hyeonjung, Kim, Semi, Lee, Hyo Jeong, Kim, Sung-Hoon, Park, Ki Hun, Kim, Hyun Jeong, Cho, Moonjae, Lee, Jung Weon
Format: Article
Language:English
Subjects:
Animals
Carcinoma, Hepatocellular - metabolism
Carcinoma, Hepatocellular - pathology
Cell Movement - physiology
Female
Hepatocytes - cytology
Hepatocytes - pathology
Hepatocytes - physiology
invadopodia
invasion
Liver Neoplasms - metabolism
Liver Neoplasms - pathology
Membrane Proteins - genetics
Membrane Proteins - metabolism
metastasis
Mice
Mice, Inbred BALB C
Mice, Nude
migration
MMP
Neoplasm Metastasis
TM4SF5
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Summary:Overexpression of transmembrane 4 L six family member 5 (TM4SF5), a four‐transmembrane L6 family member, causes aberrant cell proliferation and angiogenesis, but the roles of TM4SF5 in migration, invasion, and tumor metastasis remain unknown. Using in vitro hepatocarcinoma cells that ectopically or endogenously express TM4SF5 and in vivo mouse systems, roles of TM4SF5 in metastatic potentials were examined. We found that TM4SF5 expression facilitated migration, invadopodia formation, MMP activation, invasion, and eventually lung metastasis in nude mice, but suppression of TM4SF5 with its shRNA blocked the effects. Altogether, TM4SF5‐mediated migration and invasion suggest that TM4SF5 may be therapeutically targeted to deal with TM4SF5‐mediated hepatocellular cancers. J. Cell. Biochem. 111: 59–66, 2010. © 2010 Wiley‐Liss, Inc.
ISSN:0730-2312
1097-4644
DOI:10.1002/jcb.22662