Fracture risk assessment in Latin America: is Frax™ an adaptable instrument for the region

Osteoporosis is a generalized disease of bone that increases fracture risk. Multiple factors influence this risk, besides low bone mass. To decrease osteoporotic fractures, those patients who require preventive management should be readily identified. This paper aims to review current information on...

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Bibliographic Details
Published in:Clinical rheumatology 2010-10, Vol.29 (10), p.1085-1091
Main Authors: Morales-Torres, Jorge, Clark, Patricia, Delezé-Hinojosa, Margarita, Cons-Molina, Fidencio, Messina, Osvaldo Daniel, Hernández, Jaime, Jaller-Raad, Juan José, Quevedo-Solidoro, Héctor, Radominski, Sebastiao Cezar
Format: Article
Language:English
Subjects:
Bone Density
Case finding
epidemiology
Fragility fractures
FRAX osteoporosis
Humans
Latin America - epidemiology
Medicine
Medicine & Public Health
Osteoporotic Fractures - epidemiology
Review Article
Rheumatology
Risk
Risk Assessment
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Summary:Osteoporosis is a generalized disease of bone that increases fracture risk. Multiple factors influence this risk, besides low bone mass. To decrease osteoporotic fractures, those patients who require preventive management should be readily identified. This paper aims to review current information on the use of the fracture risk assessment tool (FRAX™) in Latin America. Bone mineral density measurement is currently the method of reference for evaluating the fracture risk and opting for treatment; but, it misses a notable proportion of individuals who have clinical risk factors for osteoporosis and fractures. FRAX™ was designed to predict the 10-year absolute risk of sustaining a major osteoporotic fracture or a hip fracture. Although data is available for several countries, from Latin America, only Argentina appears in the current version of the tool. Its present use in other Latin American countries is possible with some adaptations based in similarities of epidemiological information of each country with some of the existing databases. The cutoff value beyond which treatment should be initiated needs to be determined, based not only on clinical criteria, but also on economic considerations.
ISSN:0770-3198
1434-9949
DOI:10.1007/s10067-010-1489-0