A 67-Year-Old Woman with a Systemic Inflammatory Syndrome and Sicca

The negative result in the antinuclear antibody testing argued against Sjögren syndrome, however. Because the negative result did not match with the clinical presentation, further serial dilutions were performed, and a positive fluorescence signal was obtained with diluted serum samples.

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Bibliographic Details
Published in:Clinical chemistry (Baltimore, Md.) Md.), 2010-09, Vol.56 (9), p.1508-1509
Main Authors: BOSSUYT, Xavier, MARIËN, Godelieve, VANDERSCHUEREN, Steven
Format: Article
Language:English
Subjects:
Aged
Analytical, structural and metabolic biochemistry
Antibodies, Antinuclear - blood
Biological and medical sciences
Cysts
False Negative Reactions
Female
Fundamental and applied biological sciences. Psychology
Humans
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Imaging
Medical diagnosis
Medical sciences
Molecular biophysics
Sjogren's Syndrome - complications
Sjogren's Syndrome - diagnosis
Sjogren's Syndrome - immunology
Systemic Inflammatory Response Syndrome - complications
Systemic Inflammatory Response Syndrome - diagnosis
Systemic Inflammatory Response Syndrome - immunology
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Description
Summary:The negative result in the antinuclear antibody testing argued against Sjögren syndrome, however. Because the negative result did not match with the clinical presentation, further serial dilutions were performed, and a positive fluorescence signal was obtained with diluted serum samples.
ISSN:0009-9147
1530-8561
DOI:10.1373/clinchem.2010.150789