Two weekly sessions of combined aerobic and resistance exercise are sufficient to provide beneficial effects in subjects with Type 2 diabetes mellitus and metabolic syndrome

This study was performed to establish whether only 2 sessions per week of combined aerobic and resistance exercise are enough to reduce glycated hemoglobin (HbA(1c)) and to induce changes in skeletal muscle gene expression in Type 2 diabetes mellitus (DM2) subjects with metabolic syndrome. Eight DM2...

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Bibliographic Details
Published in:Journal of endocrinological investigation 2010-07, Vol.33 (7), p.489-495
Main Authors: Fatone, C, Guescini, M, Balducci, S, Battistoni, S, Settequattrini, A, Pippi, R, Stocchi, L, Mantuano, M, Stocchi, V, De Feo, P
Format: Article
Language:English
Subjects:
Adult
Aged
Blood Glucose - metabolism
Blood Pressure
Body Weight
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - physiopathology
Diabetes Mellitus, Type 2 - therapy
Exercise - physiology
Female
Gene Expression
Glycated Hemoglobin A - metabolism
Humans
Male
Metabolic Syndrome - complications
Metabolic Syndrome - physiopathology
Metabolic Syndrome - therapy
Middle Aged
Muscle, Skeletal - metabolism
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Summary:This study was performed to establish whether only 2 sessions per week of combined aerobic and resistance exercise are enough to reduce glycated hemoglobin (HbA(1c)) and to induce changes in skeletal muscle gene expression in Type 2 diabetes mellitus (DM2) subjects with metabolic syndrome. Eight DM2 subjects underwent a 1-yr exercise program consisting of 2 weekly sessions of 140 min that combined aerobic [at 55-70% of maximal oxygen uptake (VO(2max))] and resistance circuit training [at 60-80% of 1 repetition maximum (RM)]. The training significantly improved VO(2max) (from 33.5+/-3.8 ml/kg/min to 38.2+/-3.5 ml/kg/min, p=0.0085) and muscle strength (p
ISSN:1720-8386
DOI:10.3275/6814