Association between factor V Leiden mutation and poor pregnancy outcomes among Palestinian women

• Published in: Thrombosis research 2010-08, Vol.126 (2), p.e78-e82
• Main Authors: Hussein, Ayman S, Darwish, Hisham, Shelbayeh, Khaled
• Format: Article
• Language: English
• Subjects: Abortion, Habitual - genetics; Adult; Arabs - genetics; Case-Control Studies; Factor V - genetics; Factor V leiden mutation; Female; Hematology, Oncology and Palliative Medicine; Humans; Mutation; Pregnancy; Pregnancy Outcome - genetics; Recurrent pregnancy loss; Thrombophilia; West Bank
• ISSN: 0049-3848; 1879-2472
• DOI: 10.1016/j.thromres.2010.04.017

Abstract Pregnancy is a hypercoagulable state with increased tendency for thrombus formation, a condition that is increased when combined with acquired or inherited risk factors that lead to thrombophilia. Among the inherited risk factors is Factor V Leiden mutation, an autosomal dominant trait with reduced penetrance. The mutation seems to be associated with different poor pregnancy outcomes including recurrent miscarriages. In the present study, we performed a case-control study to investigate the association between the Leiden mutation and poor pregnancy outcome among the Palestinian population in the West bank region of Palestine. The study included 145 subjects with recurrent miscarriages and 205 matched control subjects with successful pregnancies who experienced normal delivery and no apparent complications. Leiden mutation was detected in 41 of the145 study subjects (28.2%), and in 24 of the 205 control subjects (11.7%). Subjects homozygous with the mutant allele were identified only among the test and not the control group. Data analysis indicates a significant association between the mutant allele and recurrent miscarriages (p-value < 0.05). Furthermore, this association is significant between the mutant haplotype with miscarriages compared to control group showing time effect where there is no association for miscarriages before week 10. Results here also show strong association of factor V leiden polymorphism among primary aborters compared to secondary aborters or control groups. The odds ratio for the primary aborters was 75 and p < 0.0001. In conclusion, these results provide evidence for a significant correlation between recurrent miscarriages and Factor V mutation in our population.