Targeting inflammation to slow or delay functional decline: where are we?

The role of inflammation in the pathophysiology of chronic age-related diseases is increasingly recognized, and inflammation could represent the common pathway linking diseases and disability. Thus, targeting inflammation could represent a useful strategy at preventing or delaying functional decline...

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Bibliographic Details
Published in:Biogerontology (Dordrecht) 2010-10, Vol.11 (5), p.603-614
Main Authors: Corsonello, Andrea, Garasto, Sabrina, Abbatecola, Angela Marie, Rose, Giuseppina, Passarino, Giuseppe, Mazzei, Bruno, Pranno, Luigi, Guffanti, Enrico Eugenio, Bustacchini, Silvia, Lattanzio, Fabrizia
Format: Article
Language:English
Subjects:
Activities of Daily Living
Aged
Biomedical and Life Sciences
Cell Biology
Chronic Disease
Chronic illnesses
Developmental Biology
Exercise
Frailty
Geriatrics/Gerontology
Humans
Inflammation - physiopathology
Life Sciences
Mortality
Older people
SI: Frailty
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Summary:The role of inflammation in the pathophysiology of chronic age-related diseases is increasingly recognized, and inflammation could represent the common pathway linking diseases and disability. Thus, targeting inflammation could represent a useful strategy at preventing or delaying functional decline. In this paper we review recent evidence suggesting that selected drugs, such as statins, fibrates, angiotensin converting enzyme-inhibitors and angiotensin receptor blockers, and physical exercise may be able to contrast functional decline by blunting inflammation. Results from randomized trials investigating the effects of physical activity programs on inflammation and functional decline is still limited, and further investigations are warranted.
ISSN:1389-5729
1573-6768
DOI:10.1007/s10522-010-9289-0