Ventilator-Associated Pneumonia: The Clinical Pulmonary Infection Score as a Surrogate for Diagnostics and Outcome

The Clinical Pulmonary Infection Score (CPIS) was developed to serve as a surrogate tool to facilitate the diagnosis of ventilator-associated pneumonia (VAP). The CPIS is calculated on the basis of points assigned for various signs and symptoms of pneumonia (eg, fever and extent of oxygenation impai...

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Bibliographic Details
Published in:Clinical infectious diseases 2010-08, Vol.51 (Supplement-1), p.S131-S135
Main Authors: Zilberberg, Marya D., Shorr, Andrew F.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - therapeutic use
Antibiotics
Artificial respiration
Biological and medical sciences
Biomarkers
Clinical outcomes
Clinical trials
Clinical Trials as Topic
Correlation analysis
Endpoint Determination
General aspects
Health outcomes
Hematocrit
Human infectious diseases. Experimental studies and models
Humans
Infections
Infectious diseases
Intensive care units
Medical sciences
Oxygen
Pneumology
Pneumonia
Pneumonia, Ventilator-Associated - drug therapy
Pneumonia, Ventilator-Associated - pathology
Respiratory system : syndromes and miscellaneous diseases
Severity of Illness Index
Treatment Outcome
Validation studies
Ventilator associated pneumonia
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Summary:The Clinical Pulmonary Infection Score (CPIS) was developed to serve as a surrogate tool to facilitate the diagnosis of ventilator-associated pneumonia (VAP). The CPIS is calculated on the basis of points assigned for various signs and symptoms of pneumonia (eg, fever and extent of oxygenation impairment). Although some studies suggest that a CPIS >6 may correlate with VAP, most studies indicate that the CPIS has limited sensitivity and specificity. In addition, no well-done studies validate the CPIS in either acute lung injury or trauma. The interobserver variability in CPIS calculation remains substantial, suggesting that this cannot be routinely used across multiple centers to support the conduct of randomized clinical trials. Changes in the CPIS may correlate with outcomes in VAP, but it appears that the ratio of partial pressure of arterial oxygen to the fraction of inspired oxygen is a more important marker for outcomes than the CPIS. At present, the CPIS has a limited role both clinically and as a research tool.
ISSN:1058-4838
1537-6591
DOI:10.1086/653062