Experimental Renal Hypertension in Dogs FORELIMB HEMODYNAMICS

Blood flow arid segmental intravascular pressures were measured in the pump-perfused forelimb vascular beds of 25 dogs with chronic perinephritic hypertension and 26 normotensive control dogs (either unilaterally nephrectomized or sham-operated) under pentobarbital anesthesia. Measurements were made...

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Bibliographic Details
Published in:Circulation research 1971-07, Vol.29 (1), p.51-62
Main Authors: Overbeck, Henry W, Swindall, Booker T, Cowan, Daniel F, Fleck, Michael C
Format: Article
Language:English
Subjects:
Animals
Blood Pressure
Blood Vessels - pathology
Chronic Disease
Denervation
Dogs
Feedback
Forelimb - blood supply
Hemodynamics - drug effects
Hypertension, Renal - etiology
Hypertension, Renal - pathology
Hypertension, Renal - physiopathology
Male
Methacholine Compounds - pharmacology
Nephrectomy
Regional Blood Flow
Vascular Resistance
Vasomotor System - physiopathology
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Summary:Blood flow arid segmental intravascular pressures were measured in the pump-perfused forelimb vascular beds of 25 dogs with chronic perinephritic hypertension and 26 normotensive control dogs (either unilaterally nephrectomized or sham-operated) under pentobarbital anesthesia. Measurements were made under resting conditions (pump-perfusion pressure set equal to aortic pressure) and during response to(1) stepwise changes in pump blood flow over the range 21−330 ml/min; (2) intrabrachial arterial injection of supramaximal doses of methacholine chloride; and (3) limb denervation. Total limb vascular resistance and segmental pressure gradients were calculated. In hypertensive dogs, as compared to normotensive dogs, resting blood flow was equal (P>0.3) and resting limb total vascular resistance was increased (P
ISSN:0009-7330
1524-4571
DOI:10.1161/01.RES.29.1.51