Immunoglobulin binding in cardiomyopathic hearts

Bound gamma globulin was demonstrated by the direct immunofluorescent technique in heart tissue from three patients with severe congestive cardiomyopathy. In two of these patients complement (β 1 C) was also bound to the heart muscle. Heart tissue from one of six patients who died of myocardial infa...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1971-10, Vol.44 (4), p.612-616
Main Authors: Das, S K, Callen, J P, Dodson, V N, Cassidy, J T
Format: Article
Language:English
Subjects:
Adult
Autoantibodies
Autopsy
Cardiomyopathies - immunology
Cardiomyopathies - pathology
Cell Membrane Permeability
Complement System Proteins - analysis
Fluorescent Antibody Technique
gamma-Globulins - analysis
Heart Failure - immunology
Humans
Male
Microscopy, Fluorescence
Middle Aged
Myocardial Infarction - immunology
Myocardium - immunology
Protein Binding
Rheumatic Fever - immunology
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Description
Summary:Bound gamma globulin was demonstrated by the direct immunofluorescent technique in heart tissue from three patients with severe congestive cardiomyopathy. In two of these patients complement (β 1 C) was also bound to the heart muscle. Heart tissue from one of six patients who died of myocardial infarction showed a trace of bound gamma globulin, but no bound complement. During life, the heart in advanced cardiomyopathy may preferentially fix heart-reactive immunoglobulins to specific sarcolemmal and subsarcolemmal antigens, and antiheart antibody may not be detectable in the serum.
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.44.4.612