Origin of Osteogenic Precursor Cells in Extramedullary Marrow Implants

Autologous extramedullary marrow implantation leads to the formation of a nodule consisting of bone and hemopoietic tissue. Irradiation of the marrow immediately prior to implantation with up to 1000 rads does not interfere with the regenerative process. Since this amount of radiation is lethal for...

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Bibliographic Details
Published in:Blood 1971-11, Vol.38 (5), p.569-575
Main Authors: Maniatis, Alice, Tavassoli, Mehdi, Crosby, William H.
Format: Article
Language:English
Subjects:
Animals
Bone Marrow - radiation effects
Bone Marrow Cells
Bone Marrow Transplantation
Cell Differentiation
Cell Division - radiation effects
Hematopoiesis - radiation effects
Hematopoietic Stem Cells - radiation effects
Osteogenesis - radiation effects
Radiation Effects
Rats
Transplantation, Autologous
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Summary:Autologous extramedullary marrow implantation leads to the formation of a nodule consisting of bone and hemopoietic tissue. Irradiation of the marrow immediately prior to implantation with up to 1000 rads does not interfere with the regenerative process. Since this amount of radiation is lethal for most of the hemopoietic cells the cell initiating the regeneration must be more radio resistant and is therefore probably associated with the relatively radioresistant marrow stroma. When the marrow was irradiated with 4000 rads 2 wk prior to implantation it did not regenerate even though at the time of implantation it contained numerous hemopoietic cells. This suggests that the hemopoietic cells do not play a significant role in the regeneration of marrow implants.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V38.5.569.569