CONTROL OF RESPIRATORY DISEASE IN RECRUITS WITH TYPES 4 AND 7 ADENOVIRUS VACCINES

Top., F. H., Jr., B. A. Dudding, P. K. Russell and E. L. Buescher (Walter Reed Army Institute of Research, Wash., D.C. 20012). Control of respiratory disease in recruits with types 4 and 7 adenovirus vaccines. Amer J Epidem 94: 142–146, 1971.—Simultaneous immunization of recruits in a basic combat t...

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Bibliographic Details
Published in:American journal of epidemiology 1971-08, Vol.94 (2), p.142-146
Main Authors: TOP, FRANKLIN H., DUDDING, BURTON A., RUSSELL, PHILIP K., BUESCHER, EDWARD L.
Format: Article
Language:English
Subjects:
Adenoviridae Infections - prevention & control
adenovirus
Adult
Humans
Immunization
Male
Military Medicine
recruits
respiratory diseases
Respiratory Tract Infections - prevention & control
vaccines
Viral Vaccines
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Summary:Top., F. H., Jr., B. A. Dudding, P. K. Russell and E. L. Buescher (Walter Reed Army Institute of Research, Wash., D.C. 20012). Control of respiratory disease in recruits with types 4 and 7 adenovirus vaccines. Amer J Epidem 94: 142–146, 1971.—Simultaneous immunization of recruits in a basic combat training brigade with live adenovirus type 7 and type 4 (ADV-7, ADV-4) vaccines during an outbreak of acute respiratory disease (ARD) caused by both adenovirus types led to 95% suppression of ADV-7 associated ARD and 50% reduction in total ARD hospitalizations as compared with a brigade immunized with ADV-4 vaccine alone. A small excess of ADV-4 associated ARD hospitalizations which occurred in the study brigade may have been due in part to the relatively low potency of ADV-4 vaccine used. The combined use of ADV-4 and ADV-7 vaccines proved to be a safe and effective means of controlling ARD in a military trainee population.
ISSN:0002-9262
1476-6256
DOI:10.1093/oxfordjournals.aje.a121306