Intra-uterine diagnosis of fetal sex

The ability to examine amniotic fluid obtained by amniocentesis during the second trimester of pregnancy is a significant new advance in the practice of clinical genetics.1 We here report a rapid and accurate method for determining fetal sex, which should be useful when the pregnant woman is a carri...

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Bibliographic Details
Published in:Pediatrics (Evanston) 1971-07, Vol.48 (1), p.159-160
Main Authors: Greensher, A, Gersh, R, Peakman, D, Robinson, A
Format: Article
Language:English
Subjects:
Amniocentesis
Amniotic Fluid - cytology
Female
Fetus
Fluorescent Dyes - metabolism
Humans
Male
Methods
Microscopy, Fluorescence
Pregnancy
Sex Chromosomes - metabolism
Sex Determination Analysis
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Summary:The ability to examine amniotic fluid obtained by amniocentesis during the second trimester of pregnancy is a significant new advance in the practice of clinical genetics.1 We here report a rapid and accurate method for determining fetal sex, which should be useful when the pregnant woman is a carrier of a serious sex-linked disease such as muscular dystrophy or hemophilia. The method makes use of the selective concentration of fluorescent stains by the Y chromosome in interphase cells.2,3 Recently two observers have reported their preliminary observations on amniotic fluid cells using fluorescent techniques.4,5
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.48.1.159