Extraneural metastases of astrocytomas and glioblastomas clinicopathological study of two cases and review of literature

Two cases of intracranial gliomas with extraneural metastases are described. Case 1, studied with biopsy material only, was a left malignant astrocytoma from the area of the rolandic fissure with right cervical lymph nodes metastases in a 43‐year‐old man. Case 2 was a left temporal malignant astrocy...

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Bibliographic Details
Published in:Cancer 1980-01, Vol.45 (1), p.112-125
Main Authors: Pasquier, Basile, Pasquier, Dominique, N'golet, Arthur, Panh, Meng Hong, Couderc, Pierre
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Astrocytoma - pathology
Astrocytoma - secondary
Brain Neoplasms
Child
Female
Glioma - pathology
Glioma - secondary
Humans
Lymphatic Metastasis - pathology
Male
Meningeal Neoplasms - pathology
Meningeal Neoplasms - secondary
Middle Aged
Neoplasm Seeding
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Summary:Two cases of intracranial gliomas with extraneural metastases are described. Case 1, studied with biopsy material only, was a left malignant astrocytoma from the area of the rolandic fissure with right cervical lymph nodes metastases in a 43‐year‐old man. Case 2 was a left temporal malignant astrocytoma in a 21‐year‐old woman. Fifteen days after craniotomy, a left submandibular lymph node metastasis appeared. Forty days after surgery, a ventriculoperitoneal shunt was performed. Fifty‐four days after surgery, the patient died. Autopsy revealed three liver metastases. Our review of the literature consists of 72 autopsy cases with extraneural deposits. Those metastases occurred mainly in adults (63/72) and among men (46/72). The primary glioma was supratentorial in 67 cases. Metastases were mainly pulmonary and pleural. The majority of patients (82.8%) died within 2 years after onset of symptoms. In 8 of the cases, metastasis developed without any craniotomy and in 8 other cases, through a shunt.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19800101)45:1<112::AID-CNCR2820450121>3.0.CO;2-9