Incidence of Urothelial Tumors on Rats Deficient on Essential Fatty Acids

Wistar rats were fed a diet deficient in essential fatty acids (EFA). Control animals received the same diet to which was added 5% corn oil, a source of EFA. The experimental group showed clinical and chromatographic evidences of EFA deficiency. Groups of deficient and control animals were killed at...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1980-01, Vol.64 (1), p.73-79
Main Authors: Monis, Benito, Eynard, Aldo R.
Format: Article
Language:English
Subjects:
Animals
Carcinoma, Transitional Cell - etiology
Carcinoma, Transitional Cell - pathology
Cell Division
Dietary Fats - administration & dosage
Epithelium - pathology
Fatty Acids, Essential - administration & dosage
Female
Hyperplasia - pathology
Male
Pregnancy
Rats
Urinary Tract - pathology
Urologic Neoplasms - etiology
Urologic Neoplasms - pathology
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Summary:Wistar rats were fed a diet deficient in essential fatty acids (EFA). Control animals received the same diet to which was added 5% corn oil, a source of EFA. The experimental group showed clinical and chromatographic evidences of EFA deficiency. Groups of deficient and control animals were killed at various periods up to 100 weeks of age. Of 43 EFA-deficient rats, 8 (18.6%) had papillary transitional cell tumors of the urinary tract. None of the 36 controls had tumors (P
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/64.1.73