Influence of contractile state on the size of the extracellular space in isolated ventricular myocardium

A method is described with which the extracellular space of isolated ventricular muscle can be measured accurately and continuously in the same muscle. The size of the extracellular space is shown to vary with the contractile state of the myocardium. Interventions such as quiescence, manganese and a...

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Bibliographic Details
Published in:Basic research in cardiology 1979-11, Vol.74 (6), p.604-610
Main Authors: Poole-Wilson, P A, Bourdillon, P D, Harding, D P
Format: Article
Language:English
Subjects:
Acidosis, Respiratory
Animals
Edetic Acid - metabolism
Extracellular Space - analysis
Heart - anatomy & histology
Heart Ventricles
Hypoxia
Male
Manganese - pharmacology
Muscle Contraction
Rabbits
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Summary:A method is described with which the extracellular space of isolated ventricular muscle can be measured accurately and continuously in the same muscle. The size of the extracellular space is shown to vary with the contractile state of the myocardium. Interventions such as quiescence, manganese and acidosis reduce myocardial contractility and increase the size of the extracellular space. Barium, ouabain and hypoxia cause contracture and reduce the size of the extracellular space. These changes should be taken into account when measuring intracellular electrolytes in isolated ventricular preparations.
ISSN:0300-8428
1435-1803
DOI:10.1007/BF01907502