Relapse rate of duodenal ulcer after cessation of long-term cimetidine treatment: a double-blind controlled study

Patients with a healed duodenal ulcer and who were symptom-free following 12 months of maintenance treatment with cimetidine 400 mg twice daily were randomized double-blind to a further 6 months therapy with either cimetidine 400 mg twice daily or placebo 2 tablets twice daily. Twenty-six patients r...

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Bibliographic Details
Published in:Digestive diseases and sciences 1980-02, Vol.25 (2), p.88-91
Main Authors: Korman, M G, Hetzel, D J, Hansky, J, Shearman, D J, Don, G
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Cimetidine - therapeutic use
Clinical Trials as Topic
Double-Blind Method
Duodenal Ulcer - drug therapy
Female
Follow-Up Studies
Guanidines - therapeutic use
Humans
Male
Middle Aged
Placebos
Recurrence
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Summary:Patients with a healed duodenal ulcer and who were symptom-free following 12 months of maintenance treatment with cimetidine 400 mg twice daily were randomized double-blind to a further 6 months therapy with either cimetidine 400 mg twice daily or placebo 2 tablets twice daily. Twenty-six patients received placebo and 15 patients cimetidine. Relapse was defined as symptoms for 3 out of 7 consecutive days and ulcer recurrence was confirmed by independent endoscopy. One of 15 patients on cimetidine relapsed: 20 of 26 patients on placebo relapsed. This relapse rate (77%) is similar to that found in previous studies after only 6 weeks cimetidine therapy (71%). This study suggests that 12 months cimetidine does not change the tendency of duodenal ulcer to recur and that the relapse rate is no greater than after 6 weeks cimetidine.
ISSN:0163-2116
1573-2568
DOI:10.1007/BF01308302