Inhibition of Leukocyte Adherence by 3-M Potassium Chloride Extracts of Human Colorectal Tumors

Leukocyte adherence inhibition (LAI) assays were performed to test whether peripheral blood leukocytes (PBL) from patients with colorectal cancer could be inhibited from attachment to a glass surface when tumor-associated antigens (TAA) of human colorectal tumors were present. The assays were perfor...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1980-03, Vol.64 (3), p.419-423
Main Authors: Ichiki, Albert T., Quirin, Yvonne P., Collmann, I. Reid, Sonoda, Takuo, Krauss, Stephen
Format: Article
Language:English
Subjects:
Adenocarcinoma - immunology
Adult
Aged
Antigens, Neoplasm - isolation & purification
Colonic Neoplasms - immunology
Female
Humans
Immunity, Cellular
Immunologic Techniques
In Vitro Techniques
Leukocyte Adherence Inhibition Test
Leukocytes - immunology
Male
Middle Aged
Potassium Chloride
Prognosis
Rectal Neoplasms - immunology
Time Factors
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Description
Summary:Leukocyte adherence inhibition (LAI) assays were performed to test whether peripheral blood leukocytes (PBL) from patients with colorectal cancer could be inhibited from attachment to a glass surface when tumor-associated antigens (TAA) of human colorectal tumors were present. The assays were performed with PBL from 41 patients with adenocarcinoma of the colon or rectum with 3-M KCI extracts of colorectal tumors. The results demonstrated the presence of colorectal TAA in the 3-M KCI extract of colorectal tumor materials. The reactivity of leukocytes from patients with a favorable prognosis showed an increasing LAI trend; the reactivity of leukocytes from patients with an unfavorable prognosis had a decreasing LAI trend. In individual patients, alterations in the sequential LAI results paralleled changes in the clinical status, which thus strongly indicated that the LAI assay could be of value in the assessment of antitumor immunity.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/64.3.419