Doridosine: A New Hypotensive N-Methylpurine Riboside from the Nudibranch Anisodoris nobilis

A new N-methylpurine riboside (doridosine), probably N$^{1}$-methylisoguanosine, was isolated from the digestive glands of a nudibranch. Doridosine produces prolonged hypotension and bradycardia in anesthetized rats, decreases the rate and the amplitude of contraction of guinea pig atria in vitro, a...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1980-01, Vol.207 (4427), p.193-195
Main Authors: Fuhrman, Frederick A., Fuhrman, Geraldine J., Kim, Yong H., Pavelka, Lee A., Mosher, Harry S.
Format: Article
Language:English
Subjects:
Alcohols
Animal glands
Animals
Antihypertensive Agents - isolation & purification
Bradycardia
Electrocardiography
Guanosine - analogs & derivatives
Guanosine - isolation & purification
Guanosine - pharmacology
Guinea Pigs
Heart rate
Heart Rate - drug effects
Lead
Mass spectroscopy
Mice
Mollusca - analysis
Polygraph testing
Rats
Sodium
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Summary:A new N-methylpurine riboside (doridosine), probably N$^{1}$-methylisoguanosine, was isolated from the digestive glands of a nudibranch. Doridosine produces prolonged hypotension and bradycardia in anesthetized rats, decreases the rate and the amplitude of contraction of guinea pig atria in vitro, and causes the heart rate in anesthetized mice to be reduced by 50 percent for many hours after which the animals recover completely.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.7350655