Secondary Products of Itanoxone

Itanoxone synthesis by Friedel-Crafts reaction between itaconic anhydride and 2-chlorobiphenyl was studied. Five isomers corresponding to possible impurities were prepared and studied to perfect a reliable and practical method to detect these impurities in itanoxone.

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1980-01, Vol.69 (1), p.49-53
Main Authors: Rieu, Jean-Pierre, Mouzin, Gilbert, Cousse, Henri, Boucherle, Andre
Format: Article
Language:English
Subjects:
Biphenyl Compounds - chemical synthesis
Biphenyl Compounds - isolation & purification
Butyrophenones - chemical synthesis
Butyrophenones - isolation & purification
Chromatography, Thin Layer
Hydrogenation
Hypolipidemic Agents - chemical synthesis
Hypolipidemic Agents - isolation & purification
Hypolipidemic agents-itanoxone
Hypolipidemic agents—itanoxone, synthesis, synthesis and detection of impurities
Hypouricemic agents-itanoxone
Hypouricemic agents—itanoxone, synthesis, synthesis and detection of impurities
Isomerism
Itanoxone-synthesis
Itanoxone—synthesis, synthesis and detection of impurities
synthesis
synthesis and detection of impurities
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Description
Summary:Itanoxone synthesis by Friedel-Crafts reaction between itaconic anhydride and 2-chlorobiphenyl was studied. Five isomers corresponding to possible impurities were prepared and studied to perfect a reliable and practical method to detect these impurities in itanoxone.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600690114