Contact inhibition and malignancy

The role of contact inhibition in influencing the behaviour of malignant cells is discussed in a review. Although tissue culture cannot simulate the immense complexity of the conditions in vivo , some of the distinctive features of malignant invasion can be conveniently observed with this technique....

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Bibliographic Details
Published in:Nature (London) 1979-09, Vol.281 (5729), p.259-262
Main Author: Abercrombie, M
Format: Article
Language:English
Subjects:
Animals
Cell Adhesion
Cell Movement
Cell Nucleus - ultrastructure
Cell Transformation, Neoplastic - pathology
Cells, Cultured
Contact Inhibition
Fibroblasts - cytology
Humanities and Social Sciences
multidisciplinary
Neoplasms, Experimental - pathology
review-article
Science
Science (multidisciplinary)
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Summary:The role of contact inhibition in influencing the behaviour of malignant cells is discussed in a review. Although tissue culture cannot simulate the immense complexity of the conditions in vivo , some of the distinctive features of malignant invasion can be conveniently observed with this technique. The evidence derived from this technique indicates that defective contact inhibition of movement of malignant cells does contribute to their invasiveness.
ISSN:0028-0836
1476-4687
DOI:10.1038/281259a0