Nucleotide sequence of a region of human mitochondrial DNA containing the precisely identified origin of replication

A fragment of HeLa cell mitochondrial DNA containing the origin of replication has been sequenced. The precise position of the origin in this sequence has been identified by determining the nucleotide order in the 5 ′-end proximal portion of the heavy strand initiation fragment ( 7 S DNA), and by al...

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Bibliographic Details
Published in:Nature (London) 1979-01, Vol.277 (5693), p.192-198
Main Authors: Crews, Stephen, Ojala, Deanna, Posakony, James, Nishiguchi, Jerry, Attardi, Giuseppe
Format: Article
Language:English
Subjects:
Base Sequence
DNA Replication
DNA, Mitochondrial - genetics
HeLa Cells
Humanities and Social Sciences
Humans
Hydrogen Bonding
Mitochondria - physiology
Molecular Weight
multidisciplinary
Nucleic Acid Conformation
Science
Science (multidisciplinary)
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Summary:A fragment of HeLa cell mitochondrial DNA containing the origin of replication has been sequenced. The precise position of the origin in this sequence has been identified by determining the nucleotide order in the 5 ′-end proximal portion of the heavy strand initiation fragment ( 7 S DNA), and by aligning the two sequences.
ISSN:0028-0836
1476-4687
DOI:10.1038/277192a0