Human EEG response to beta-endorphin

Beta-endorphin, morphine, and saline were given intravenously to a single schizophrenic subject on separate occasions in a double-blind design. EEG spectral analyses performed on data collected before and after drug injection demonstrated that β-endorphin and morphine produced similar increases in a...

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Bibliographic Details
Published in:Psychiatry research 1979-07, Vol.1 (1), p.83-88
Main Authors: Pfefferbaum, Adolf, Berger, Philip A., Elliot, Glen R., Tinklenberg, Jared R., Kopell, Bert S., Barchas, Jack D., Li, Choh Hao
Format: Article
Language:English
Subjects:
Adult
Alpha Rhythm
Beta-endorphin
Brain - drug effects
EEG
Endorphins - pharmacology
Humans
Male
morphine
Morphine - pharmacology
schizophrenia
Schizophrenia, Paranoid - physiopathology
spectral analysis
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Summary:Beta-endorphin, morphine, and saline were given intravenously to a single schizophrenic subject on separate occasions in a double-blind design. EEG spectral analyses performed on data collected before and after drug injection demonstrated that β-endorphin and morphine produced similar increases in alpha power within 5 to 15 minutes after injection. This effect could be distinguished from two placebo (saline) injections. These data suggest that intravenous β-endorphin can produce changes in the central nervous system in humans.
ISSN:0165-1781
1872-7123
DOI:10.1016/0165-1781(79)90031-3