Mapping of metabolites in whole animals by 31P NMR using surface coils

The metabolic state of skeletal muscle and brain within intact rats is monitored using high resolution phosphorus nuclear magnetic resonance. Regional disturbances in metabolism (for example, localised ischaemia) are easily observed, indicating the diagnostic possibilities of the method. Measurement...

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Bibliographic Details
Published in:Nature (London) 1980-01, Vol.283 (5743), p.167-170
Main Authors: Ackerman, Joseph J. H., Grove, Thomas H., Wong, Gordon G., Gadian, David G., Radda, George K.
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - metabolism
Animals
Brain - metabolism
Energy Metabolism
Humanities and Social Sciences
Hydrogen-Ion Concentration
Ischemia - metabolism
Magnetic Resonance Spectroscopy - instrumentation
Magnetic Resonance Spectroscopy - methods
Models, Structural
multidisciplinary
Muscles - blood supply
Muscles - metabolism
Phosphates - metabolism
Phosphocreatine - metabolism
Rats
Science
Science (multidisciplinary)
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Summary:The metabolic state of skeletal muscle and brain within intact rats is monitored using high resolution phosphorus nuclear magnetic resonance. Regional disturbances in metabolism (for example, localised ischaemia) are easily observed, indicating the diagnostic possibilities of the method. Measurements are made using ‘surface’ radio-frequency coils, which we discuss in detail.
ISSN:0028-0836
1476-4687
DOI:10.1038/283167a0