Estrogen receptor protein in malignant carcinoid tumor a report of 2 cases

Two cases of metastatic malignant carcinoid tumor in elderly women contained significant amounts of estrogen receptor (19 and 32 femtomoles/mg protein) as shown by Scatchard‐plot analysis of a dextran‐coated charcoal assay, inhibition of binding by an estrogen analog (67 and 63%) and high‐affinity b...

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Bibliographic Details
Published in:Cancer 1980-01, Vol.45 (2), p.293-296
Main Authors: Keshgegian, Albert A., Wheeler, James E.
Format: Article
Language:English
Subjects:
Aged
Carcinoid Tumor - metabolism
Carcinoid Tumor - pathology
Carcinoid Tumor - secondary
Estradiol - metabolism
Female
Humans
Ileal Neoplasms - metabolism
Liver Neoplasms - metabolism
Neoplasms, Hormone-Dependent - metabolism
Receptors, Estrogen - genetics
Receptors, Estrogen - metabolism
Suppression, Genetic
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Summary:Two cases of metastatic malignant carcinoid tumor in elderly women contained significant amounts of estrogen receptor (19 and 32 femtomoles/mg protein) as shown by Scatchard‐plot analysis of a dextran‐coated charcoal assay, inhibition of binding by an estrogen analog (67 and 63%) and high‐affinity binding (Kd = 6.8 and 2.6 × 10−10 M). The demonstration of estrogen receptor in malignant carcinoid tumor expands the spectrum of non‐breast or non‐gynecologic neoplasms that contain the receptor. The significance of estrogen receptor in such tumors is uncertain; it may represent aberrant derepression of the gene for estrogen receptor protein in a malignant tumor.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19800115)45:2<293::AID-CNCR2820450216>3.0.CO;2-5