Tissue Distribution of Antitumor Drugs Associated with Polyalkylcyanoacrylate Nanoparticles

• Published in: Journal of pharmaceutical sciences 1980-02, Vol.69 (2), p.199-202
• Main Authors: Couvreur, P., Kante, B., Lenaerts, V., Scailteur, V., Roland, M., Speiser, P.
• Format: Article
• Language: English
• Subjects: Adsorption; Animals; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - metabolism; compared to polyethylcyanoacrylate nanoparticles; compared to polymethylcyanoacrylate nanoparticles; Cyanoacrylates - metabolism; Dactinomycin - metabolism; Dactinomycin-on polymethylcyanoacrylate and polyethylcyanoacrylate nanoparticles; Dactinomycin—on polymethylcyanoacrylate and polyethylcyanoacrylate nanoparticles, distribution patterns in rats; distribution patterns in rats; distribution patterns of adsorbed dactinomycin and vinblastine in rats; Drug carriers-polymethylcyanoacrylate and polyethylcyanoacrylate nanoparticles; Drug carriers—polymethylcyanoacrylate and polyethylcyanoacrylate nanoparticles, distribution patterns of adsorbed dactinomycin and vinblastine in rats; Drug Stability; In Vitro Techniques; Microspheres; Polyethylcyanoacrylate nanoparticles-with adsorbed dactinomycin and vinblastine; Polyethylcyanoacrylate nanoparticles—with adsorbed dactinomycin and vinblastine, distribution patterns in rats, compared to polymethylcyanoacrylate nanoparticles; Polymethylcyanoacrylate nanoparticles-with adsorbed dactinomycin and vinblastine; Polymethylcyanoacrylate nanoparticles—with adsorbed dactinomycin and vinblastine, distribution patterns in rats, compared to polyethylcyanoacrylate nanoparticles; Rats; Time Factors; Tissue Distribution; Vinblastine - metabolism; Vinblastine-on polymethylcyanoacrylate and polyethylcyanoacrylate nanoparticles; Vinblastine—on polymethylcyanoacrylate and polyethylcyanoacrylate nanoparticles, distribution patterns in rats
• ISSN: 0022-3549; 1520-6017
• DOI: 10.1002/jps.2600690222

Polymethylcyanoacrylate nanoparticles, polyethylcyanoacrylate nanoparticles, and free 3H-dactinomycin and 3H-vinblastine were studied with emphasis on their distribution pattern in rat tissues after intravenous administration. The adsorption of cytostatic drugs to polyalkylcyanoacrylate nanoparticles can modify drug distribution in tissues. Particularly with vinblastine, modification of drug disposition is important. Data are given concerning the formation and stability of nanoparticle-drug complexes. Polyalkylcyanoacrylate nanoparticles seem to be an interesting drug carrier owing to their size, structure, degradability, and drug sorptive properties.