Hepatic monoamine oxidase deficiency in Reye syndrome

Faraj et al1 recently reported a positive correlation between plasma tyramine levels and the number of days in coma, for patients with biopsy-proven Reye's syndrome. They suggested that the mitochondrial injury might have a disruptive effect upon hepatic monoamine oxidase, with a subsequent dec...

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Bibliographic Details
Published in:Pediatrics (Evanston) 1980-03, Vol.65 (3), p.673-673
Main Authors: Mitchell, R A, Arcinue, E L
Format: Article
Language:English
Subjects:
Humans
Liver - enzymology
Mitochondria, Liver - enzymology
Monoamine Oxidase - metabolism
Reye Syndrome - enzymology
Tyramine - blood
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Summary:Faraj et al1 recently reported a positive correlation between plasma tyramine levels and the number of days in coma, for patients with biopsy-proven Reye's syndrome. They suggested that the mitochondrial injury might have a disruptive effect upon hepatic monoamine oxidase, with a subsequent decrease in clearance of tyramine. We have reached a similar conclusion on the possible role of tyramine in the development of the encephalopathy, based on the finding that the hepatic monoamine oxidase activity was reduced about 60% in stage V Reye's syndrome patients.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.65.3.673