The Effect of Antiarrhythmic Drugs on Depressed Conduction and Unidirectional Block in Sheep Purkinje Fibres

We studied the effect of therapeutic of lidocaine, procainamide, quinidine, propranolol, and diphenylhydantion on two models of depressed conduction and unidiectional block peoduced by asymmetric focal cooling and crushing in sheep Purkinje fibres. All drugs were shwon to induce reversible deteriora...

Full description

Saved in:
Bibliographic Details
Published in:Circulation research 1980-05, Vol.46 (5), p.612-619
Main Authors: Wald, Robert W, Waxman, Memanshe B, Downar, Eugene
Format: Article
Language:English
Subjects:
Animals
Anti-Arrhythmia Agents
Heart Block - physiopathology
Heart Conduction System - drug effects
Heart Conduction System - physiopathology
Lidocaine - pharmacology
Phenytoin - pharmacology
Procainamide - pharmacology
Purkinje Fibers - drug effects
Purkinje Fibers - physiopathology
Quinidine - pharmacology
Sheep
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We studied the effect of therapeutic of lidocaine, procainamide, quinidine, propranolol, and diphenylhydantion on two models of depressed conduction and unidiectional block peoduced by asymmetric focal cooling and crushing in sheep Purkinje fibres. All drugs were shwon to induce reversible deterioration of conduction. Unidirectional block was converted to bidirectional block to bidirectional conduction never was observed. These experiments suggest that all five drgus may act by a uniform mechanism of action of some reetrant ventricular arrhythmias involving a zone of depressed conduction or unidirectional block within the Purkinje network. Circ Res 46612-619, 1980
ISSN:0009-7330
1524-4571
DOI:10.1161/01.RES.46.5.612