Hypoplastic and fibrotic sinus node associated with intractable tachycardia in a neonate

A case of fetal and neonatal persistent atrial tachycardia is described in a child with complete transposition of the great arteries. At autopsy, serial sections of the conducting tissue showed that the sinus node was hypoplastic and markedly fibrotic. The sinus node consisted of a small area of cel...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1980-05, Vol.61 (5), p.1048-1052
Main Authors: Fox, K M, Anderson, R H, Hallidie-Smith, K A
Format: Article
Language:English
Subjects:
Ductus Arteriosus, Patent - diagnosis
Ductus Arteriosus, Patent - pathology
Electrocardiography
Female
Heart Atria - pathology
Heart Block - etiology
Heart Rate
Heart Septal Defects, Atrial - pathology
Humans
Infant, Newborn
Infant, Newborn, Diseases - etiology
Male
Pregnancy
Sinoatrial Node - abnormalities
Sinoatrial Node - pathology
Tachycardia - etiology
Tachycardia - pathology
Transposition of Great Vessels - diagnosis
Transposition of Great Vessels - pathology
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Description
Summary:A case of fetal and neonatal persistent atrial tachycardia is described in a child with complete transposition of the great arteries. At autopsy, serial sections of the conducting tissue showed that the sinus node was hypoplastic and markedly fibrotic. The sinus node consisted of a small area of cells clustered around the nodal artery. Although the underlying mechanism of neonatal persistent tachycardia is unclear, it is possible that the hypoplasia and fibrosis of the sinus node was the substrate in the present case. This mechanism should be considered in any newborn infant in whom sinus rhythm cannot be established.
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.61.5.1048