FR-31564, A NEW PHOSPHONIC ACID ANTIBIOTIC: BACTERIAL RESISTANCE AND MEMBRANE PERMEABILITY

Mutants which acquired resistance to FR-31564 were also resistant to fosfomycin and vice versa. Some exceptions to cross-resistance were found among clinical isolates of certain species. FR-31564 was found to be incorporated into bacterial cells more efficiently than fosfomycin although the extent o...

Full description

Saved in:
Bibliographic Details
Published in:Journal of antibiotics 1980, Vol.33(1), pp.44-48
Main Authors: KOJO, HITOSHI, SHIGI, YASUTAKA, NISHIDA, MINORU
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Bacteria - drug effects
Bacteria - metabolism
Carbohydrate Metabolism
Cell Membrane Permeability
Drug Resistance, Microbial
Drug Stability
Fosfomycin - analogs & derivatives
Fosfomycin - metabolism
Fosfomycin - pharmacology
Mutation
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Mutants which acquired resistance to FR-31564 were also resistant to fosfomycin and vice versa. Some exceptions to cross-resistance were found among clinical isolates of certain species. FR-31564 was found to be incorporated into bacterial cells more efficiently than fosfomycin although the extent of incorporation varied among species. In particular, the uptake rate of FR-31564 by a strain of Pseudomonas aeruginosa was ten times that of fosfomycin. The uptake rate of FR-31564 by both FR-31564- and fosfomycin-resistant Mutants was less than one-tenth of that by the parent strain. FR-31564 was scarcely inactivated in the culture broths of FR-31564-resistant strains. All of the FR-31564-resistant mutants of P. aeruginosa came under the classification of strains lacking an L-α-glycerophosphate transport system.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.33.44