Activation of the alternative pathway of complement by Malassezia ovalis (Pityrosporum ovale)

Activation of C3 and factor B in normal human serum by P. ovale was demonstrated using a standard unidirectional immunoelectrophoresis technique. Activation of complement by the alternative (properdin) pathway is a possible mechanism by which P. ovale may mediate an inflammatory response.

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Bibliographic Details
Published in:Mycopathologia (1975) 1980-01, Vol.70 (3), p.187-191
Main Authors: Belew, P.W, Rosenberg, E.W, Jennings, B.R
Format: Article
Language:English
Subjects:
Complement Activation
Complement C3 - metabolism
Complement C3b - metabolism
Complement Factor B - metabolism
Complement Pathway, Alternative
fungi
Humans
Immunoelectrophoresis
Malassezia - immunology
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Description
Summary:Activation of C3 and factor B in normal human serum by P. ovale was demonstrated using a standard unidirectional immunoelectrophoresis technique. Activation of complement by the alternative (properdin) pathway is a possible mechanism by which P. ovale may mediate an inflammatory response.
ISSN:0301-486X
1573-0832
DOI:10.1007/bf00443030