Proliferation of Lethally Damaged Mammalian Cells Irradiated by Fast Electrons, Fast Neutrons, α Particles, and Pions

Proliferation of lethally damaged tumor cells was determined after irradiation with fast electrons, fast neutrons, α particles, and pions in the peak and plateau of the depth dose curve. The method used was measurement of the proliferation of the total population, $N_{{\rm tot}}$, and the subpopulat...

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Bibliographic Details
Published in:Radiation research 1980-05, Vol.82 (2), p.352-363
Main Authors: Heyder, I. R., Pohlit, W.
Format: Article
Language:English
Subjects:
Alpha Particles
Animals
Carcinoma, Ehrlich Tumor - pathology
Carcinoma, Ehrlich Tumor - radiotherapy
Cell Count
Cell Division - radiation effects
Cell growth
Cell lines
Cell Survival - radiation effects
Cells, Cultured
DNA damage
Dosimetry
Electrons
Elementary Particles
Fast Neutrons
Irradiation
Mice
Neoplasms, Experimental - pathology
Neoplasms, Experimental - radiotherapy
Pions
Radiation damage
Radiation dosage
Radiotherapy
Radiotherapy - methods
Space life sciences
Tumors
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Summary:Proliferation of lethally damaged tumor cells was determined after irradiation with fast electrons, fast neutrons, α particles, and pions in the peak and plateau of the depth dose curve. The method used was measurement of the proliferation of the total population, $N_{{\rm tot}}$, and the subpopulation of viable cells which are able to grow to macrocolonies after irradiation, $N_{{\rm m}}$. The difference between these populations ($N_{{\rm tot}}-N_{{\rm m}}$) then represents the lethally damaged cells. The number of cell divisions after irradiation decreases with increasing absorbed dose in the same way for all the different types of radiation if related to the survival of cells, S. Consequences for the type of lethal radiation damage in mammalian cells and for radiotherapy are discussed.
ISSN:0033-7587
1938-5404
DOI:10.2307/3575385