Feeding Increases Dopamine Metabolism in the Rat Brain

Feeding induced by food deprivation is accompanied by an increased production of the dopamine metabolite 3,4-dihydroxyphenylacetic acid in the brains of rats. This neurochemical change occurs in the nucleus accumbens, the posterior hypothalamus, and the amygdala but not in other dopaminergic nerve t...

Full description

Saved in:
Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1980-06, Vol.208 (4448), p.1168-1170
Main Authors: Heffner, Thomas G., Hartman, John A., Seiden, Lewis S.
Format: Article
Language:English
Subjects:
3,4-Dihydroxyphenylacetic Acid - metabolism
Amygdala
Amygdala - metabolism
Animals
Brain
Brain - metabolism
Dopamine - metabolism
Eating
Food
Food access
Food consumption
Food Deprivation
Hypothalamus - metabolism
Male
Neurons
Nucleus accumbens
Nucleus Accumbens - metabolism
Posterior hypothalamus
Putamen - metabolism
Rats
Satiation - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Feeding induced by food deprivation is accompanied by an increased production of the dopamine metabolite 3,4-dihydroxyphenylacetic acid in the brains of rats. This neurochemical change occurs in the nucleus accumbens, the posterior hypothalamus, and the amygdala but not in other dopaminergic nerve terminal fields such as the corpus striatum. These results indicate that the release of dopamine from particular groups of central neurons is increased during feeding and suggest that anatomically distinct subgroups of central dopaminergic neurons serve different roles in the regulation of food intake.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.7375926