Unequal crossing-over: a common basis of single alpha-globin genes in Asians and American blacks with hemoglobin-H disease

The α-globin genes of five black Americans, two Chinese, and five Filipinos with HbH disease (an α-thalassemia state in which there is a single functional α gene) were analyzed by restriction endonuclease techniques. All subjects were found to have one chromosome 16, lacking both α genes, and anothe...

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Bibliographic Details
Published in:Blood 1980-06, Vol.55 (6), p.1066-1069
Main Authors: Phillips, John A., Vik, Terry A., Scott, Alan F., Young, Keith E., Kazazian, Haig H., Smith, Kirby D., Fairbanks, Virgil F., Koenig, Harold M.
Format: Article
Language:English
Subjects:
Black or African American
Black People
China
Chromosome Deletion
Crossing Over, Genetic
DNA Restriction Enzymes
Genes
Globins - genetics
Hemoglobin H - genetics
Hemoglobins, Abnormal - genetics
Humans
Philippines
Thalassemia - genetics
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Summary:The α-globin genes of five black Americans, two Chinese, and five Filipinos with HbH disease (an α-thalassemia state in which there is a single functional α gene) were analyzed by restriction endonuclease techniques. All subjects were found to have one chromosome 16, lacking both α genes, and another containing a single α gene ( –/-α). Restriction endonuclease patterns of the DNA obtained from all 12 subjects were identical and compatible with unequal crossing-over as the mechanism of origin of the single α gene in these individuals.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V55.6.1066.1066