Effects of Hypokalemia on the Cardiotropic Actions of Digoxin in Dogs: Correlation with Inhibition of Cardiac Na+,K+-Adenosine Triphosphatase

Hypokalemia potentiated the arryhthmogenic effects of digoxin and promoted inhibition of cardiac Na,K-ATPase. Acute hypokalemia did not modify digoxin-induced inotropy and therefore altered the quantitative relationship between inhibition of Na,K-ATPase and positive inotropy. Chronic hypokalemia imp...

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Bibliographic Details
Published in:Circulation research 1980-06, Vol.46 (6 Suppl I), p.I-173-I-174
Main Authors: GELBART, ALEX, HALL, ROGER J, GOLDMAN, ROBERT
Format: Article
Language:English
Subjects:
Acute Disease
Adenosine Triphosphatases - antagonists & inhibitors
Animals
Chronic Disease
Digoxin - administration & dosage
Digoxin - pharmacology
Dogs
Hypokalemia - physiopathology
Isoproterenol - pharmacology
Myocardial Contraction - drug effects
Potassium - antagonists & inhibitors
Sodium - antagonists & inhibitors
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Summary:Hypokalemia potentiated the arryhthmogenic effects of digoxin and promoted inhibition of cardiac Na,K-ATPase. Acute hypokalemia did not modify digoxin-induced inotropy and therefore altered the quantitative relationship between inhibition of Na,K-ATPase and positive inotropy. Chronic hypokalemia impaired the positive inotropic response to digoxin and to isoproterenol in the absence of an electron microscopically detectable cardiomyopathy.
ISSN:0009-7330
1524-4571