STUDIES ON ANTITUMOR ACTIVITY OF PRUMYCIN: IV. EFFECT OF PRUMYCIN ON MOUSE IMMUNE SYSTEM

The effect of prumycin on the mouse immune system was studied. Prumycin at a dose of 75 mg/kg (1/2LD50) Showed essentially no suppression of hemolytic plaque forming cells (PFC) against sheep red blood cells (SRBC) when it was administered on day 0, 1 or 2. However, a weak suppression was observed b...

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Bibliographic Details
Published in:Journal of antibiotics 1980, Vol.33(2), pp.231-235
Main Authors: OKUBO, SHUJI, MORIMOTO, MAKOTO, MINEURA, KAZUYUKI, MARUMO, HIROFUTO, OMURA, SATOSHI
Format: Article
Language:English
Subjects:
Amino Sugars - pharmacology
Animals
Antibiotics, Antineoplastic - pharmacology
Antibody Formation - drug effects
Arabinose - analogs & derivatives
Arabinose - pharmacology
Erythrocytes - immunology
Hypersensitivity, Delayed - physiopathology
Immunity - drug effects
Immunity, Cellular - drug effects
Lymphocytes - drug effects
Mice
Sheep - immunology
Spleen - cytology
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Summary:The effect of prumycin on the mouse immune system was studied. Prumycin at a dose of 75 mg/kg (1/2LD50) Showed essentially no suppression of hemolytic plaque forming cells (PFC) against sheep red blood cells (SRBC) when it was administered on day 0, 1 or 2. However, a weak suppression was observed by administration of prumycin on day 3. Also a remarkable suppression of PFC was demonstrated when mouse spleen cells were pre-incubated with prumycin at the concentration over 62.5 mg/kg in vitro. The delayed-type hypersensitivity reaction against SRBC was remarkably suppressed by cyclophosphamide, but it was not much by prumycin, except by administration on the day of elicitation. Prumycin of a high concentration inhibited an uptake of 3H-thymidine by mouse spleen lymphocytes incubated with or without phytohemagglutinin, but that of a low concentration, 1.9-0.03 mcg/ml, slightly increased the blastogenic stimulation of lymphocytes.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.33.231