Antibody levels in mothers colonised with group B streptococci during pregnancy and in their newborn infants, as measured by an enzyme linked immunosorbent assay

An enzyme-linked immunosorbent assay (ELISA) was developed to measure serum antibodies to group B streptococci in 20 healthy pregnant women before delivery and in their newborn infants. The sera from 10 of these women who were colonised with group B streptococci and umbilical cord sera from their in...

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Bibliographic Details
Published in:Medical microbiology and immunology 1980-02, Vol.168 (1), p.49-53
Main Authors: Cleat, P H, Ross, J, Needham, J R
Format: Article
Language:English
Subjects:
Antibodies, Bacterial - analysis
Antibody Specificity
Carrier State - immunology
Enzyme-Linked Immunosorbent Assay
Female
Fetal Blood - immunology
Humans
Immunoglobulin A - analysis
Immunoglobulin G - analysis
Immunoglobulin M - analysis
Infant, Newborn
Pregnancy
Pregnancy Complications, Infectious - immunology
Streptococcal Infections - immunology
Streptococcus agalactiae - immunology
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Summary:An enzyme-linked immunosorbent assay (ELISA) was developed to measure serum antibodies to group B streptococci in 20 healthy pregnant women before delivery and in their newborn infants. The sera from 10 of these women who were colonised with group B streptococci and umbilical cord sera from their infants, had higher levels of type-specific IgG antibody than the 10 non-colonised controls and their neonates. All the babies remained well. The results demonstrate that infants from colonised mothers receive type-specific antibody. The possibility that this antibody may provide some degree of protection at birth against this potentially lethal organism warrants investigation.
ISSN:0300-8584
1432-1831
DOI:10.1007/BF02121651