Richter's syndrome with identification of marker chromosomes

A case is presented of a man with Richter's syndrome with diffuse histiocytic lymphoma following a ten‐year history of untreated chronic lymphatic leukemia. He did not respond to therapy. The lymphoma cells had 61 chromosomes with aneuploidy of 13 chromosomes and 11 structurally altered chromos...

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Bibliographic Details
Published in:Cancer 1980-07, Vol.46 (1), p.135-138
Main Authors: Fitzgerald, P. H., McEwan, Christine M., Hamer, J. W., Beard, M. E. J.
Format: Article
Language:English
Subjects:
Aneuploidy
Chromosome Aberrations
Chromosome Banding
Genetic Markers
Humans
Leukemia, Lymphoid - complications
Leukemia, Lymphoid - genetics
Leukemia, Lymphoid - ultrastructure
Lymphocytes - ultrastructure
Lymphoma, Large B-Cell, Diffuse - complications
Lymphoma, Large B-Cell, Diffuse - genetics
Lymphoma, Large B-Cell, Diffuse - ultrastructure
Male
Middle Aged
Translocation, Genetic
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Summary:A case is presented of a man with Richter's syndrome with diffuse histiocytic lymphoma following a ten‐year history of untreated chronic lymphatic leukemia. He did not respond to therapy. The lymphoma cells had 61 chromosomes with aneuploidy of 13 chromosomes and 11 structurally altered chromosomes. Only chromosomes 8, 9, 12, 14, and 18 were diploid and without abnormality. Significantly, part of chromsome 1q was duplicated as in the partial trisomy of 1q reported to characterize a number of hematologic neoplasms. A large marker chromosome with subterminal centromere was a tandem duplication of chromosome 4q. Cancer 46:135–138, 1980.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19800701)46:1<135::AID-CNCR2820460121>3.0.CO;2-N