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Distinct age-related changes in the urinary catabolic profile of prostaglandin F2 alpha in the rat
Seven urinary catabolites were identified after intravenous infusion of tritium-labeled prostaglandin F2 alpha in the adult rat. Most products were the result of oxidation at C-15, reduction of the delta 13,14 double bond, and double beta oxidation together with omega oxidation reactions yielding 14...
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| Published in: | The Journal of biological chemistry 1980-07, Vol.255 (13), p.6106-6110 |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c311t-86a571f797975a9869e084308f34f99ca8c9d2710bca7d07e7d0928a46542f313 |
| container_end_page | 6110 |
| container_issue | 13 |
| container_start_page | 6106 |
| container_title | The Journal of biological chemistry |
| container_volume | 255 |
| creator | C R Pace-Asciak N S Edwards |
| description | Seven urinary catabolites were identified after intravenous infusion of tritium-labeled prostaglandin F2 alpha in the adult
rat. Most products were the result of oxidation at C-15, reduction of the delta 13,14 double bond, and double beta oxidation
together with omega oxidation reactions yielding 14 and 16 carbon compounds. While the former sequence of reactions is also
demonstrable in the neonate (2 weeks and older), the omega oxidation system develops around 28 to 32 days of age. Consequently,
the urinary catabolic pattern resulting from infusion of tritiated prostaglandin F2, in the rat younger than 32 days is composed
principally of one product identified as 15-keto-13,14-dihydrotetranor prostaglandin F2 alpha (VII). This product is one of
the transient intermediates in the adult and is catabolized further by omega oxidation. |
| doi_str_mv | 10.1016/S0021-9258(18)43707-6 |
| format | article |
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rat. Most products were the result of oxidation at C-15, reduction of the delta 13,14 double bond, and double beta oxidation
together with omega oxidation reactions yielding 14 and 16 carbon compounds. While the former sequence of reactions is also
demonstrable in the neonate (2 weeks and older), the omega oxidation system develops around 28 to 32 days of age. Consequently,
the urinary catabolic pattern resulting from infusion of tritiated prostaglandin F2, in the rat younger than 32 days is composed
principally of one product identified as 15-keto-13,14-dihydrotetranor prostaglandin F2 alpha (VII). This product is one of
the transient intermediates in the adult and is catabolized further by omega oxidation.</description><identifier>ISSN: 0021-9258</identifier><identifier>EISSN: 1083-351X</identifier><identifier>DOI: 10.1016/S0021-9258(18)43707-6</identifier><identifier>PMID: 7391007</identifier><language>eng</language><publisher>United States: American Society for Biochemistry and Molecular Biology</publisher><subject>Aging ; Animals ; Chemical Phenomena ; Chemistry ; Chromatography, Gas ; Chromatography, High Pressure Liquid ; Infusions, Parenteral ; Male ; Oxidation-Reduction ; Prostaglandins F - urine ; Rats</subject><ispartof>The Journal of biological chemistry, 1980-07, Vol.255 (13), p.6106-6110</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c311t-86a571f797975a9869e084308f34f99ca8c9d2710bca7d07e7d0928a46542f313</citedby><cites>FETCH-LOGICAL-c311t-86a571f797975a9869e084308f34f99ca8c9d2710bca7d07e7d0928a46542f313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7391007$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>C R Pace-Asciak</creatorcontrib><creatorcontrib>N S Edwards</creatorcontrib><title>Distinct age-related changes in the urinary catabolic profile of prostaglandin F2 alpha in the rat</title><title>The Journal of biological chemistry</title><addtitle>J Biol Chem</addtitle><description>Seven urinary catabolites were identified after intravenous infusion of tritium-labeled prostaglandin F2 alpha in the adult
rat. Most products were the result of oxidation at C-15, reduction of the delta 13,14 double bond, and double beta oxidation
together with omega oxidation reactions yielding 14 and 16 carbon compounds. While the former sequence of reactions is also
demonstrable in the neonate (2 weeks and older), the omega oxidation system develops around 28 to 32 days of age. Consequently,
the urinary catabolic pattern resulting from infusion of tritiated prostaglandin F2, in the rat younger than 32 days is composed
principally of one product identified as 15-keto-13,14-dihydrotetranor prostaglandin F2 alpha (VII). This product is one of
the transient intermediates in the adult and is catabolized further by omega oxidation.</description><subject>Aging</subject><subject>Animals</subject><subject>Chemical Phenomena</subject><subject>Chemistry</subject><subject>Chromatography, Gas</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Infusions, Parenteral</subject><subject>Male</subject><subject>Oxidation-Reduction</subject><subject>Prostaglandins F - urine</subject><subject>Rats</subject><issn>0021-9258</issn><issn>1083-351X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><recordid>eNo9kFtLxDAQhYMo63r5CUJAEH2oZpqmSR7FOwg-qOBbmKbpNtJt1yaL-O_NXjQDSWDOmZx8hJwAuwQG5dUrYzlkOhfqHNRFwSWTWblDpsAUz7iAj10y_Zfsk4MQPllahYYJmUiugTE5JdWtD9H3NlKcuWx0HUZXU9tiP3OB-p7G1tHl6Hscf6jFiNXQeUsX49D4ztGhWV1DxFmHfZ3k9znFbtHin3XEeET2GuyCO96eh-T9_u7t5jF7fnl4url-ziwHiJkqUUhopE4lUKtSO6YKzlTDi0Zri8rqOpfAKouyZtKlTecKi1IUecOBH5KzzdyU6GvpQjRzH6zrUjI3LIORAmQqkYRiI7QpehhdYxajn6cPGmBmxdas2ZoVOAPKrNmaMvlOtg8sq7mr_11bmKl_uum3ftZ--9GZyg-2dXOTC2GAmxJYyX8Bvd5_fA</recordid><startdate>19800710</startdate><enddate>19800710</enddate><creator>C R Pace-Asciak</creator><creator>N S Edwards</creator><general>American Society for Biochemistry and Molecular Biology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19800710</creationdate><title>Distinct age-related changes in the urinary catabolic profile of prostaglandin F2 alpha in the rat</title><author>C R Pace-Asciak ; N S Edwards</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-86a571f797975a9869e084308f34f99ca8c9d2710bca7d07e7d0928a46542f313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Aging</topic><topic>Animals</topic><topic>Chemical Phenomena</topic><topic>Chemistry</topic><topic>Chromatography, Gas</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Infusions, Parenteral</topic><topic>Male</topic><topic>Oxidation-Reduction</topic><topic>Prostaglandins F - urine</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>C R Pace-Asciak</creatorcontrib><creatorcontrib>N S Edwards</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of biological chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>C R Pace-Asciak</au><au>N S Edwards</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distinct age-related changes in the urinary catabolic profile of prostaglandin F2 alpha in the rat</atitle><jtitle>The Journal of biological chemistry</jtitle><addtitle>J Biol Chem</addtitle><date>1980-07-10</date><risdate>1980</risdate><volume>255</volume><issue>13</issue><spage>6106</spage><epage>6110</epage><pages>6106-6110</pages><issn>0021-9258</issn><eissn>1083-351X</eissn><abstract>Seven urinary catabolites were identified after intravenous infusion of tritium-labeled prostaglandin F2 alpha in the adult
rat. Most products were the result of oxidation at C-15, reduction of the delta 13,14 double bond, and double beta oxidation
together with omega oxidation reactions yielding 14 and 16 carbon compounds. While the former sequence of reactions is also
demonstrable in the neonate (2 weeks and older), the omega oxidation system develops around 28 to 32 days of age. Consequently,
the urinary catabolic pattern resulting from infusion of tritiated prostaglandin F2, in the rat younger than 32 days is composed
principally of one product identified as 15-keto-13,14-dihydrotetranor prostaglandin F2 alpha (VII). This product is one of
the transient intermediates in the adult and is catabolized further by omega oxidation.</abstract><cop>United States</cop><pub>American Society for Biochemistry and Molecular Biology</pub><pmid>7391007</pmid><doi>10.1016/S0021-9258(18)43707-6</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-9258 |
| ispartof | The Journal of biological chemistry, 1980-07, Vol.255 (13), p.6106-6110 |
| issn | 0021-9258 1083-351X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75171715 |
| source | ScienceDirect Journals |
| subjects | Aging Animals Chemical Phenomena Chemistry Chromatography, Gas Chromatography, High Pressure Liquid Infusions, Parenteral Male Oxidation-Reduction Prostaglandins F - urine Rats |
| title | Distinct age-related changes in the urinary catabolic profile of prostaglandin F2 alpha in the rat |
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